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“Engine manufacturers want to test at these levels – engines are running hotter and at higher pressures, which transfers to higher frequencies and greater g-levels.

Robust operation follows from electrical working principles that tolerate fluctuations in supply voltage during weak NFC coupling to the reader antenna. Because a nonregulated harvesting circuit scheme yields the highest possible efficiency, and therefore the longest operational distance, the analog front end must operate in a manner that is independent of voltage supply to allow for variances in magnetic resonant power transfer and, thus, stable operation in practical scenarios. Using a zero-crossover operational amplifier accomplishes this goal due to the wide operational voltage window that conditions the sensor signal without distortion, regardless of supply voltage. SPICE (Simulation Program with Integrated Circuit Emphasis) software simulation reveals the behavior of the biofuel cell–based lactate and glucose sensors signal conditioning when subject to varying supply voltage (fig. S2). Figure S2 (C and D) confirms stable data acquisition over the entire range of supply voltages. Figure 2 (G and H) shows experimental validation through studies of the effect of distance and angle between three separate devices and a handheld reader with antenna size comparable to a smartphone (5 cm by 3 cm) on sensor signal quality for the case of a constant reference sensor signal (100 mV). In these experiments, a constant current reference signal, applied to the wireless electronics with a 1-megohm load via a constant current source, simulates an electrochemical cell analogous to the glucose sensor configuration. Figure 2G illustrates that the reader records stable signal from the devices at a distance up to ~38 mm. Figure 2H shows the reader’s capability for recording uninterrupted, constant signals from the devices at angles up to 70°, with voltage errors of only 2 mV throughout the test, which corresponds to an acceptable variation of ~10 μM for the glucose sensor and ~0.2 mM for the lactate sensor, as described subsequently. A distance of ~1 cm is maintained between the device and the reader while studying the effect of orientation between the device and electronics. These results demonstrate the broad range of conditions over which reliable data can be acquired.

Under the ICH guidelines, countries are grouped into different climatic zones. The idea is that manufacturers can use these zones to determine the type of testing that is likely to be required in a particular market and include it in their programs.

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Stability testing can be carried out in-house or by dedicated service providers. Source BioScience provides outsourced stability storage services to many global pharmaceutical companies. In addition, the company offers complementary analytical testing services at its facility in Stirling, UK. Due to increasing demand, Source BioScience is currently in the process of expanding its analytical testing capabilities to offer these services from a second site in Rochdale, UK, with further plans to expand into Europe and the USA. With the facilities and expertise to support clients through the entire stability testing and batch release process, Source BioScience provides a full range of tailored solutions to the pharmaceutical industry, which also includes clinical trial support.  

• 7-Eleven No. 409, 3402 University Ave.: cold hold food held at improper temperatures. Corrected on site. Observed unsealed drywall behind the boxes. Observed holes in ceiling above area above boxes and above electrical boxes. Observed soiled ceiling vent in dry storage area. Corrected by next routine inspection.

Did you know the Queen of England wears Essie Nail Color in Ballet Slippers exclusively? It’s true, and one of the many reasons we’re not surprised this gorgeous neutral maintains its rank. Read more about the Queen’s nail polish habits.

Made in Korea and formulated without any parabens, The Face Shop facial mask sheets are coated in a nourishing serum that not only hydrates dry skin, but even helps minimize the appearance of pores as well as remove blackheads. These masks are also suitable for all skin types, and are also great for soothing irritated areas. This set includes variations like pomegranate, honey, olive, and avocado.

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If you’re already investing in one of the bestselling drugstore shampoos, it makes sense to pair it with the perfect drugstore conditioner counterpart. L’Oreal Paris Elvive Total Repair 5 Repairing Conditioner is the deep-hydration conditioner counterpart to our first shampoo on this list, and is the perfect detangling boost dry hair desperately needs.

Although these assays have an irreversible response, time-dependent changes in sweat composition can be captured by using fluidic designs that enable time-sequential sampling (chrono-sampling) of sweat using passive valve constructs (40, 45). The example in fig. S8A uses collections of CBVs to enable sequential filling of a series of independent microreservoirs, each pre-impregnated with a colorimetric reagent. Briefly, CBV #1 has the smallest bursting pressure (BP) due to its wide channel width (200 μm) and small diverging outlet angle (21°). CBV #2 has the second smallest BP due to its larger diverging angle (90°) with a width that is the same as that of CBV #1. When sweat encounters the intersection between CBV #1 and CBV #2, it flows through CBV #1 due to its smaller BP. After filling the chamber, the sweat flows to CBV #2 because CBV #3 has the highest BP due to its small width (50 μm). The sweat gland generates fluidic pressure through osmotic effects associated with the concentration difference between sweat and plasma. The microfluidic platform contains CBVs specially designed to open within the physiological range of sweat pressures. Hence, the pressure generated by the glands themselves is sufficient to open each chamber (39, 45). Using this process, the device collects and stores sweat in time sequence in separate chambers. The left and right sides of the device provide chrono-sampling analysis of pH and chloride, respectively.